Cancer-driving DNA rings silenced by trapping them outside cell nucleus
Researchers found that trapping extrachromosomal DNA rings outside the cell nucleus may silence their genes. These rings often carry oncogenes linked to aggressive tumors.
This finding may help in developing new cancer treatments, though it is based on lab research.
What are ecDNA rings
Extrachromosomal DNA rings are circular DNA fragments found in rapidly growing, highly metastatic tumors. They often contain oncogenes that promote cancer.
How researchers approached the problem
Scientists sought vulnerabilities in these DNA rings to stop their activity. They tested methods to trap the rings outside the cell nucleus.
Common questions
What did the researchers discover about trapping ecDNA
Trapping ecDNA rings outside the cell nucleus may silence their genes. This could be a potential strategy for targeting cancer-driving DNA.
Sources
- Trapping cancer-driving DNA rings outside cell nucleus silences their genes, researchers find MedicalXpress · medicalxpress.com
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